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. 2014 Nov 14;9(11):e112871. doi: 10.1371/journal.pone.0112871

Table 4. Homolog proteins to accessory proteins of the insect circadian clock.

Organism Protein Clock function C. elegans homolog E value
Drosophila melanogaster VRI 2nd loop K08F8.2 (ATF-2) 1.70E-17
PDP1E 2nd loop ZK909.4 (CES-2) 2.00E-06
CWO 3rd loop None none
CREB Modulator Y41C4A.4d (CRH-1d) 8.10E-43
DBT Modulator C03C10.1 (KIN-19) 5.30E-190
CK2A Modulator B0205.7 (KIN-3) 3.50E-209
CK2B Modulator T01G9.6b (KIN-10) 1.50E-121
SGG Modulator Y18D10A.5 (GSK-3) 3.30E-189
PP1 PP1b Modulator F29F11.6a (GSP-1a) 1.30E-216
PP1-13C Modulator F56C9.1 (GSP-2) 1.30E-218
PP2 PP2a_MTS Modulator Y75B8A.30 (PPH-4.1) 3.90E-177
PP2a_TWS Modulator F26E4.1 (SUR-6) 4.00E-213
PP2a_WBT_A Modulator W08G11.4 (PPTR-1) 4.30E-256
PP2a_WBT_B Modulator C13G3.3c (PPTR-2c) 9.50E-279
PRMT-5 Modulator C34E10.5 (PRMT-5) 3.70E-144
SLMB Modulator K10B2.1 (LIN-23) 1.90E-232
RH1 Modulator C52B11.3 (DOP-4) 8.60E-34
RH5 Modulator C52B11.3 (DOP-4) 4.00E-30
RH6 Modulator C52B11.3 (DOP-4) 8.40E-30
NMO Modulator W06F12.1e (LIT-1e) 1.50E-182
NOCTE Modulator None None
NORPA Modulator B0348.4a (EGL8a) 0
TO Output None None
PDF Output T07E3.6b (PDF-1) 3.00E-02
PDFR Output C13B9.4a (PDFR-1a) 1.80E-127
SLO Output Y51A2D.19a (SLO-1a) 0
NA Output C11D2.6a (UNC-77a) 0
IR Output M02A10.2a (IRK-2a) 8.50E-159
JET Output C02F5.7a 8.80E-128
CSN4 Output Y55F3AM.15 (CSN-4) 7.80E-85
PKA Output ZK909.2h (KIN-1h) 1.60E-217
EBONY Output Y66D12A.14 1.40E-60
LRK Output F18H3.3b (PAB-2b) 1.80E-36
FER2 Output B0304.1b (HLH-1b) 1.90E-12
JAFRAC Output F09E5.15a (PRDX-2a) 5.10E-105
WDS-PB Output C14B1.4 (WDR-5.1) 3.50E-165

These proteins are the best hits found by probabilistic inference search based on Hidden Markov Models built upon multiple protein alignments of the accessory proteins of the circadian clock of insects (D. melanogaster). Those proteins that did not possess the same domains that the query profile are highlighted (bold). Common C. elegans names are enclosed between parenthesis when available.