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. 2014 Nov 14;9(11):e113081. doi: 10.1371/journal.pone.0113081

Table 2. Voxel-based morphometry results showing regions of significant grey matter intensity decrease for contrasts across patient samples (bvFTD, SD, AD) in comparison with Controls.

MNI coordinates
Contrast Regions Side Number of voxels x y z T value
BvFTD vs. Controls Right cerebellum, right inferior temporal gyrus, right temporal pole, right parahippocampal gyrus, right hippocampus, right amygdala, right thalamus, right insular cortex, right orbitofrontal cortex, right medial PFC, right frontal pole, extending into left frontal pole, left medial PFC, left orbitofrontal cortex, left anterior cingulate, left insular cortex, left parahippocampal cortex, left amygdala, left hippocampus, left temporal pole, left inferior temporal gyrus B 67,718 18 −62 −64 4.11
Cerebellum L 2,707 −26 −84 −52 4.11
SD vs. Controls Temporal fusiform cortex, temporal pole, parahippocampal gyrus, amygdala, hippocampus, insular cortex, orbitofrontal cortex, frontal pole L 20,159 −24 −6 −52 4.14
Temporal fusiform cortex, temporal pole, parahippocampal gyrus, amygdala, hippocampus, insular cortex, orbitofrontal cortex R 6,885 34 −8 −52 4.14
Cerebellum L 1,250 −26 −82 −54 3.86
AD vs. Controls Right temporal fusiform cortex, right parahippocampal gyrus, right amygdala, right hippocampus, right supramarginal gyrus, right orbitofrontal cortex, right frontal pole, extending into left frontal pole, left inferior temporal gyrus, left parahippocampal gyrus, left hippocampus, left supramarginal gyrus, left superior parietal lobule, left lateral occipital cortex, left precuneus B 68,010 30 −2 −54 4.02

All clusters reported using threshold free cluster enhancement technique (tfce) and corrected for Family-Wise Error (FWE) at p<.001. For brevity only those clusters above 1,000 contiguous voxels are reported here. BvFTD = behavioural-variant frontotemporal dementia; SD = semantic dementia; AD = Alzheimer's disease; L = Left; R = Right; B = Bilateral; MNI = Montreal Neurological Institute.