Table 2. Voxel-based morphometry results showing regions of significant grey matter intensity decrease for contrasts across patient samples (bvFTD, SD, AD) in comparison with Controls.
MNI coordinates | |||||||
Contrast | Regions | Side | Number of voxels | x | y | z | T value |
BvFTD vs. Controls | Right cerebellum, right inferior temporal gyrus, right temporal pole, right parahippocampal gyrus, right hippocampus, right amygdala, right thalamus, right insular cortex, right orbitofrontal cortex, right medial PFC, right frontal pole, extending into left frontal pole, left medial PFC, left orbitofrontal cortex, left anterior cingulate, left insular cortex, left parahippocampal cortex, left amygdala, left hippocampus, left temporal pole, left inferior temporal gyrus | B | 67,718 | 18 | −62 | −64 | 4.11 |
Cerebellum | L | 2,707 | −26 | −84 | −52 | 4.11 | |
SD vs. Controls | Temporal fusiform cortex, temporal pole, parahippocampal gyrus, amygdala, hippocampus, insular cortex, orbitofrontal cortex, frontal pole | L | 20,159 | −24 | −6 | −52 | 4.14 |
Temporal fusiform cortex, temporal pole, parahippocampal gyrus, amygdala, hippocampus, insular cortex, orbitofrontal cortex | R | 6,885 | 34 | −8 | −52 | 4.14 | |
Cerebellum | L | 1,250 | −26 | −82 | −54 | 3.86 | |
AD vs. Controls | Right temporal fusiform cortex, right parahippocampal gyrus, right amygdala, right hippocampus, right supramarginal gyrus, right orbitofrontal cortex, right frontal pole, extending into left frontal pole, left inferior temporal gyrus, left parahippocampal gyrus, left hippocampus, left supramarginal gyrus, left superior parietal lobule, left lateral occipital cortex, left precuneus | B | 68,010 | 30 | −2 | −54 | 4.02 |
All clusters reported using threshold free cluster enhancement technique (tfce) and corrected for Family-Wise Error (FWE) at p<.001. For brevity only those clusters above 1,000 contiguous voxels are reported here. BvFTD = behavioural-variant frontotemporal dementia; SD = semantic dementia; AD = Alzheimer's disease; L = Left; R = Right; B = Bilateral; MNI = Montreal Neurological Institute.