Table 5. Tract-based spatial statistics results showing regions of white matter integrity decrease in each of the patient groups compared with Controlsa .
MNI coordinates | |||||||
Contrast | Tracts | Side | Number of voxels | x | y | z | T value |
BvFTD versus Controls | Inferior longitudinal fasciculus, uncinate fasciculus, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, anterior thalamic radiation, forceps minor, forceps major, cingulum (cingulate gyrus), cingulum (hippocampal part), superior longitudinal fasciculus (temporal part) | B | 64,986 | −28 | 0 | −36 | 4.14 |
SD versus Controls | Inferior longitudinal fasciculus, uncinate fasciculus | L | 2,096 | −34 | −3 | −34 | 2.53 |
AD versus Controls | Forceps major, forceps minor, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, uncinate fasciculus, cingulum (cingulate gyrus) | B | 31,691 | −24 | −56 | 11 | 3.49 |
Diffusion tensor imaging data not available for 1 bvFTD patient. Age is included as a covariate in all contrasts. All clusters reported using threshold-free cluster enhancement method and corrected for Family-Wise Error (FWE) at p<.05. BvFTD = behavioural-variant frontotemporal dementia; SD = semantic dementia; AD = Alzheimer's disease; L = Left; B = Bilateral; MNI = Montreal Neurological Institute.