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. 2014 Nov 5;14:811. doi: 10.1186/1471-2407-14-811

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© Tae et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunohistochemical staining of adiponectin, AdipoR1, and AdipoR2. (a–c) Localization of adiponectin staining in normal colon tissue (a, ×200), advanced adenoma (b, ×200) and CRC (c, ×200) differed from spindle-shaped cells in the subepithelial area to a diffuse area in the lamina propria. (d–i) Staining for AdipoR1 (d, ×200) and AdipoR2 (g, ×200) was positive in the epithelium of normal colon tissues. AdipoR1 (e, ×400) and AdipoR2 (h, ×100) showed moderate staining intensities in the epithelial layer of advanced adenoma. In CRC, AdipoR1 (f, ×400) and AdipoR2 (i, ×100) showed weak or no staining.