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. 2014 Nov 13;11:188. doi: 10.1186/s12974-014-0188-1

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© Castellazzi et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Affinity ratio distributions. Affinity ratio (AR) values of anti-Epstein Barr nuclear antigen 1 (EBNA-1) IgG and of anti-viral capsid antigen (VCA) IgG in cerebrospinal fluid (CSF) and serum from 50 relapsing-remitting multiple sclerosis (RRMS), 50 other inflammatory neurological disease (OIND) and 50 noninflammatory neurological disease (NIND) patients. Anti-EBNA-1 IgG and anti-VCA IgG CSF AR values were significantly higher in RRMS and OIND than in NIND (panels A and B; Mann- Whitney with Bonferroni correction; P <0.0001), without any further statistical differences between RRMS and controls for anti-EBNA-1 IgG and anti-VCA IgG serum AR values (panels C and D). Each point represents a single observation, excluding outliers. Horizontal bars indicate medians and error bars correspond to the standard error.