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. 2014 Oct 26;9:42. doi: 10.1186/1750-1326-9-42

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© Yuzwa et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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O -GlcNAc levels are increased in the TAPP mouse brain. A. Western blots of total brain homogenates from 0, 200 and 500 mkd Thiamet-G treated TAPP mice reveals that O-GlcNAc levels are vastly increased (RL2 and CTD110.6) while actin indicates equal protein loading. B. Quantification of O-GlcNAc immunoreactivity (CTD110.6) normalized to actin by densitometry of all bands (left panel) or only the low molecular weight (MW) bands (bands <50 kDa, right panel). N =10 in each group. *indicates p <0.05, ***indicates p <0.001, unpaired two-tailed t-test) C. Immunohistochemical (IHC) analysis of 0 and 500 mkd Thiamet-G treated TAPP mice brain tissue reveals that O-GlcNAc levels are increased in all of the hippocampus (A’, E’), cerebellum (B’, F’), pons (C’, G’) and the amygdala (D’ , H’).