Figure 10.

Complete open reading frame sequences of representative GnRH receptors, aligned using Clustal X [ 58 ]. Arrowheads indicate intron-exon boundaries. Locations of transmembrane domains (TM) are estimated based on those illustrated in [25] and in [10]. a = GnRH binding site for Type I receptors [59]; b = G_s coupling site in Type I receptors [24]; c = GnRH2 binds receptors containing D at this position, and does not bind receptors containing an N at this position [56]; d = GnRH binding site in both Type I and II receptors [24,55]; e = G_q/11 coupling site in Type I receptors [24]; f = GnRH binding site in Type II receptors [55]; g = sites contributing to differential sensitivity to GnRH1 and GnRH2 [57]; h = site involved in activation of the adenylyl cyclase/protein kinase A signaling pathway [60]; i = site involved in rapid internalization of Type II receptors [61].