Table 3.

Biochemistry parameters in CDDP and THD groups at 6 and 12 months

	CDDP group			THD group
	Baseline (n = 38)	6 months (n = 38)	12 months (n = 34)	Baseline (n = 30)	6 months (n = 30)	12 months (n = 29)	P
Triglycerides (mg/dL)	109 ± 36	134 ± 92	126 ± 50	131 ± 72	152 ± 67	139 ± 52	0.03
Total Cholesterol (mg/dL)	164 ± 36	168 ± 36	164 ± 35	165 ± 41	168.5 ± 34	170 ± 40	0.51
HDL Cholesterol (mg/dL)	44 ± 14	47 ± 13	48 ± 20	44 ± 12	45 ± 13	44 ± 12	0.58
LDL Cholesterol (mg/dL)	101 ± 29	93 ± 34	93 ± 31	95 ± 32	93 ± 29	97.8 ± 34	0.95
Cholinesterases (UI/mL)	5474 ± 1396	6073 ± 1474	586 ± 1646	4968 ± 1488	5511 ± 1604	4673 ± 1450b	0.27
Uric acid (mg/dL)	7.3 ± 2.3	7.5 ± 2.4	7.1 ± 1.9	6.4 ± 1.8b	7.3 ± 1.2	7.2 ± 1.3b	0.60
Sodium (mmol/L)	139 ± 2.6	137 ± 3.6	137 ± 4.0	138 ± 2.7	138 ± 2.3	134 ± 3.3	0.58
Potassium (mmol/L)	4.4 ± 0.6	4.3 ± 0.6	4.3 ± 0.7	4.3 ± 0,67	4.7 ± 0.7	4.8 ± 0.9b	0.07
Calcium (mg/dL)	9.2 ± 0.5	9.0 ± 0.5	9.1 ± 0.6	9.1 ± 0.6	9.1 ± 0.7	9.0 ± 0.5	0.51
Phosphatemia (mg/dL)	4.4 ± 0.9	4.6 ± 0.8	4.6 ± 0.8	5.1 ± 1.5	5.6 ± 1.1	5.2 ± 1.1	0.001
Bicarbonate (mEq/L)	22.0 ± 3.1	23.1 ± 3.3	23.2 ± 3.2	21.8 ± 4.2	21.9 ± 3.2	21.6 ± 2.7	0.17
β2-microglobulin (mg/dL)	14.2 ± 3.9	16.8 ± 5.7	16.0 ± 5.1	18.4 ± 11.6	31.0 ± 16.0	28.0 ± 11.4b	0.007
Hb (g/dl)	10.8 ± 0.1	11.5 ± 0.95	11.5 ± 0.97a	10.5 ± 1.4	11.3 ± 0.9	11.2 ± 0.95a	0.31
EPO (IU/kg/week)	104 ± 108	69 ± 59	60 ± 74b	184 ± 84	172 ± 138	204 ± 252	0.002
ERI (IU/kg/week)/Hb	10 ± 11	6 ± 5	5 ± 7b	19 ± 10	15 ± 13	19 ± 23	<0.001
CRP (% patients) <5.0	89	81.5	79	66.6	83.3	76.6	<0.05
CRP (mg/dL)	3.3 ± 3.9	3.5 ± 3.3	3.2 ± 3.6	8.6 ± 9.7	4.9 ± 6.5	5.8 ± 5.8	<0.01
iPTH (ρg/mL) <150 (%)	39.5	52.6	52	36.7	43.3	34.5	0.09
iPTH (ρg/mL) 150–300 (%)	29	29	30	13.3	20	27.6	0.26
iPTH (ρg/mL) >300 (%)	31.5a	18.4	18a	50	36.7	37.9	0.02

Changes versus baseline: ^ap < 0.01; ^bp < 0.03; P: ANOVA significance for treatment by time interaction.