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. 2014 Nov 4;12:308. doi: 10.1186/s12967-014-0308-9

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© Zhang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Co-localization of LMFs and NK cells in hepatitis B related LF patients and phenotypic characterization of LMFs. (A) CD56⁺ NK cells infiltrate the diseased liver tissues (bar, 100 μm), and a high level of α-SMA is expressed in both chronic (CLF) and acute (ALF) hepatitis B related LF patients (bar, 200 μm). 1 of 15 representative micrographs is shown. (B) Confocal immunofluorescence shows that CD56⁺ NK cells are in close proximity to LMFs (α-SMA⁺) at the sites of liver inflammation, and 1 of 15 representative micrographs is shown. Bar, 50 μm. (C) Immunofluorescence staining of LMFs isolated from representative samples of LF patients. Bar, 20 μm. (D) The surface markers of LMFs cultured for 3-5 population doublings were analyzed by flow cytometry (open profiles, isotype; black filled profiles, stained with indicated Abs). The percentage of positive cells is shown.