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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Curr Opin Hematol. 2014 Sep;21(5):380–387. doi: 10.1097/MOH.0000000000000066

FIGURE 2.

FIGURE 2

A detailed view of HIT disorder and therapy. There are three potential routes to TF-mediated thrombin generation, resulting in the final step of platelet–fibrin thrombi. On the left, the locus of current therapy directed at thrombin generation and action (T1) is compared with alternative and combination novel therapies geared to formation of the IC (T2) or inhibition of IC-mediated platelet activation (T3). Hep, heparin; HIT, heparin-induced thrombocytopenia; IC, immune complex; PF4, platelet factor 4; TF, tissue factor.