Table 1.
Code | Percentage w/w of different components in formulation | Mean droplet size ±S.D. (nm) | PDI±S.D. | Mean zeta potential ±S.D.(mv) | ||
---|---|---|---|---|---|---|
Oil(20%) | Polyol(75%) | Phospholipid(5%) | ||||
DPF | MCT | Fructose | Lipoid S75 | 142.3 ± 4.3 | 0.12 ± 0.02 | -18.36 ± 0.37 |
DPG | MCT | Glycerol | Lipoid S75 | 147.3 ± 6.1 | 0.12 ± 0.01 | -18.29 ± 0.16 |
DPS | MCT | Sucrose | Lipoid S75 | 148.5 ± 10.9 | 0.11 ± 0.02 | -18.49 ± 0.10 |
PDI indicates polydispersity index.
DPF, DPG and DPS: dibudipine Phytosolve formulation which contained fructose solution, glycerol and sucrose solution as polyol phase respectively.
Dibudipine was dissolved in MCT (10 mg/g) in all the formulation (DPF, DPG, DPS).