Table 3.
The precision and accuracy of dibudipine determination in rat plasma
| Sample concentration (ng/mL) | 10(LLOQ) a | 100(low) | 500(Medium) | 1000(High) |
|---|---|---|---|---|
| Intra-day(n=5) | ||||
| Mean ± S.D. | 9.2 ± 0.7 | 91.4 ± 4.1 | 450.0 ± 18.7 | 940.0 ± 41.8 |
| CV (%) b | 8.1 | 4.5 | 4.15 | 4.4 |
| Error (%) c | -7.8 | -7.6 | -10.0 | -6.0 |
| Inter-day(n=5) | ||||
| Mean ± S.D. | 9.1 ± 0.3 | 90.8 ± 2.9 | 502.0 ± 37.0 | 920.0 ± 25.5 |
| CV (%) | 3.8 | 3.2 | 7.3 | 2.7 |
| Error (%) | -9.0 | -9.2 | 0.4 | -8.0 |
The measured concentration minus the expected concentration to the expected concentration × 100.
a
LLOQ: lower limit of quantification
b
Precision (at each concentration) was expressed as CV% = (SD/ mean measured concentration) × 100
c
Accuracy (at each concentration) was expressed as the Error%, which was calculated by dividing