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. 2014 Nov 13;2:e645. doi: 10.7717/peerj.645

Figure 6. A geometric view of the correction process, showing the tetrahedron of all nucleotide distributions.

Figure 6

When the true nucleotide distribution p is (1, 0, 0, 0), the limiting distribution after next generation sequencing q is along the line from p to the centroid c. Under sampling, we see nearby qˆ which is corrected to rˆ, lying on the extension of the line from c to qˆ.