Table 3.
PNH and thrombosis: The incidence and localization of thrombotic events in our series prior Eculizumab
| Parker’s classification | Classic | SBMD | Subclinical |
|---|---|---|---|
| Number of patients | 29 | 20 | 7 |
| Thrombosis cases (%) | 12 (41) | 4 (20) | 4 (57) |
| Thrombotic episodes | 25 | 6 | 6 |
| Deep calf | 5 | 3 | 2 |
| Cerebral ischemic infarcts | 3 | 1 | |
| Large cerebrovascular | 2 (1 death) | 3 (1 death) | |
| Budd–Chiari | 1 | 1 | 1 |
| Portal | 2 | 1 (1 death) | |
| Retinal | 2 | ||
| Cava | 1 | ||
| PTE | 2 (1 death) | ||
| Myocardial infarct | 3 (1 death) | ||
| Arterial ischemia | 2 (1 amputation) | ||
| Skin ischemic | 2 (vasculitis, livedo reticularis) |
PNH, paroxysmal nocturnal hemoglobinuria; SBMD, PNH in the setting of another specified bone marrow disorder; PTE, pulmonary thromboembolism.