Table 3.
Association of FCGR3A and FCGR3B CNVs with RA susceptibility*
|
FCGR3A |
FCGR3B |
|||
|---|---|---|---|---|
| RA | Controls | RA | Controls | |
| Unadjusted | ||||
| CN <2 | 36 (3.81) | 19 (1.34) | 98 (10.35) | 126 (8.97) |
| CN = 2 | 836 (88.47) | 1,280 (90.14) | 685 (72.33) | 1,026 (73.02) |
| CN >2 | 73 (7.72) | 121 (8.52) | 164 (17.32) | 253 (18.01) |
| χ2 | 15.5197 | 1.3208 | ||
| P | 4.27 × 10−4 | 0.5167 | ||
| Fisher's exact P | 5.00 × 10−4 | 0.5160 | ||
| Adjusted for age and sex | ||||
| CN >2 vs. CN = 2 | ||||
| P | 0.3335 | 0.4320 | ||
| PFDR | 0.432 | 0.432 | ||
| OR (95% CI) | 0.86 (0.62−1.17) | 0.91 (0.72−1.15) | ||
| CN <2 vs. CN = 2 | ||||
| P | 5.83 × 10−4 | 0.3584 | ||
| PFDR | 0.0012 | 0.3584 | ||
| OR (95% CI) | 2.82 (1.56−5.1) | 1.15 (0.85−1.55) | ||
*
Except where indicated otherwise, values are the number (%). CNVs = copy number variations; RA = rheumatoid arthritis; PFDR = false discovery rate–adjusted P value; OR = odds ratio; 95% CI = 95% confidence interval.