Table 2.
Effects of HNHA on body and organ weight changes in BDL rats
| Groups | Body weight (g) | Organ weight | ||||
|---|---|---|---|---|---|---|
| Liver (g) | Spleen (g) | Liver/body (%) | Spleen/body (%) | |||
| SHAM | Veh | 346 ± 7.9 | 14.00 ± 0.29 | 1.07 ± 0.07 | 3.86 ± 0.11 | 0.30 ± 0.05 |
| Meloxicam | 368 ± 9.0 | 14.35 ± 0.33 | 1.12 ± 0.05 | 3.89 ± 0.10 | 0.30 ± 0.02 | |
| SAHA | 360 ± 4.2 | 13.56 ± 0.19 | 1.08 ± 0.02 | 3.76 ± 0.05 | 0.29 ± 0.03 | |
| HNHA | 353 ± 5.9 | 13.65 ± 0.17 | 1.03 ± 0.09 | 3.86 ± 0.07 | 0.29 ± 0.05 | |
| BDL | Veh | 298 ± 4.7 | 21.13 ± 1.02 | 2.09 ± 0.12 | 7.08 ± 0.95 | 0.70 ± 0.11 |
| Meloxicam | 308 ± 5.5*;##; | 18.00 ± 0.97*;##; | 1.80 ± 0.55*;##; | 5.84 ± 0.45*;##; | 0.58 ± 0.05*;#; | |
| SAHA | 311 ± 6.4*;#; | 15.74 ± 0.51**;#; | 1.52 ± 0.43**;#; | 5.06 ± 0.41**;#; | 0.49 ± 0.52**;#; | |
| HNHA | 324 ± 5.1**; | 14.05 ± 2.06***; | 1.32 ± 0.55***; | 4.33 ± 0.54**; | 0.40 ± 0.05**; | |
Meloxicam was injected i.m. at a daily dose of 1.6 mg, and SAHA and HNHA were injected i.p. in rats at a dose of 30 mg·kg−1 once every 3 days for 3 weeks. Data shown are means ± SEM.
*
P < 0.05,
**
P < 0.01,
***
P < 0.005 versus BDL;
#
P < 0.05,
##
P < 0.01 versus BDL + HNHA.