Table 2.

Combined effects of age and reproductive history on interest in genetic testing in 100% penetrance and clinical utility scenario

Age and Reproductive History	Individuals with epilepsy			Biological relatives without epilepsy
	N	% Definitely/probably yes	p-valuea	N	% Definitely/probably yes	p-valuea
<40 years
No children	15	86.7	Ref.	17	64.7	Ref.
Have children	13	100.0	0.16	21	95.2	0.009
None affected	10	100.0	0.16	19	100.0	0.002
≥1 affected	3	100.0	0.16	2	50.0	0.72
40–59 years
No children	22	86.4	Ref.	18	88.9	Ref.
Have children	45	80.0	0.50	55	70.9	0.08
None affected	33	75.8	0.33	45	64.4	0.03
≥1 affected	12	91.7	0.61	10	100.0	0.17
≥60 years
No children	12	100.0	Ref.	5	60.0	Ref.
Have children	33	78.8	0.007	47	72.3	0.62
None affected	14	85.7	0.16	22	72.7	0.62
≥1 affected	19	73.7	0.02	25	72.0	0.64

^ap-value from robust Poisson regression with generalized estimating equations, compared with reference group (denoted by Ref.).