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Caudate hypo-activations in response to gains and penalties in MDD. Left and right caudate emerged from the map of significant group differences (controls > MDD) in responses to gains and penalties outcomes vs. responses to neutral outcome (p < 0.005 or Z > 2.58, uncorrected for multiple comparisons across voxels).
| Region | Cluster size (#) | X | Y | Z | Z score |
|---|---|---|---|---|---|
| Gain + Penalty outcome > Neutral outcome (HC > MDD) | |||||
| Left Caudate | 59 | −8 | 0 | 14 | 3.64 |
| Right Caudate | 42 | 14 | 20 | 8 | 3.43 |
