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. 2014 Oct 29;15:419. doi: 10.1186/1745-6215-15-419

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© Gillard et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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H5N1 haemagglutination inhibition antibody response against the heterologous A/Indonesia/05/2005 strain. Vaccination groups are: 1xH5N1-AS, single dose of the AS03_A-adjuvanted vaccine; 1xH5N1, single dose of the non-adjuvanted vaccine; 2xH5N1-AS, double dose of the AS03_A-adjuvanted vaccine; 2xH5N1, double dose of the non-adjuvanted vaccine. Seroconversion rate (SCR) was defined as the percentage of participants with either a pre-vaccination titre <1:10 and a post-vaccination titre ≥1:40, or a pre-vaccination titre ≥1:10 and a ≥4-fold increase in post-vaccination titre; and seroprotection rate (SPR) was defined as the percentage of participants with a haemagglutination inhibition titre ≥1:40. GMT, geometric mean titre. Error bars indicate the 95% confidence intervals. Post-vaccination = day 42. Post-vaccination results are shown for the according-to-protocol immunogenicity cohort (1xH5N1-AS: N =152, 1xH5N1: N = 54, 2xH5N1-AS: N = 145, 2xH5N1: N = 44); month 12 and month 24 results for the month 24 according-to-protocol persistence cohort (1xH5N1-AS: N = 86, 1xH5N1: N = 37, 2xH5N1-AS: N = 81, 2xH5N1: N =24); N = maximum number of participants with available results.