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TG2 distribution in HEK293TG cells under stressful conditions. a, b Under nutrient-deprived conditions, TG2 is found in protein aggregates (a) and within autophagosomes (b). c, d Treatment with an uncoupler of oxidative phosphorylation in mitochondrial systems induces clearly visible injury of mitochondria (m); under these conditions, immuno-gold detection shows the presence of TG2 inside damaged mitochondria (N nucleus). Bars 0.3 μm
