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. Author manuscript; available in PMC: 2014 Nov 16.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Sep 8;(9):CD007396. doi: 10.1002/14651858.CD007396.pub2

Comparison 2. Meptazinol versus pethidine.

Outcome or subgroup title No. of No. of studies participants Statistical method Effect size
1 Maternal pain relief poor or none (3-5 PN) 1 801 Risk Ratio (M-H, Fixed, 95% CI) 1.01 [0.91, 1.12]
2 Pain intensity 4 or 5 on 5-point scale (1 hour) 2 239 Risk Ratio (M-H, Random, 95% CI) 1.11 [0.69, 1.80]
3 Additional analgesia required 2 233 Risk Ratio (M-H, Fixed, 95% CI) 1.03 [0.88, 1.20]
4 Epidural 4 788 Risk Ratio (M-H, Fixed, 95% CI) 0.96 [0.71, 1.29]
5 Nausea and vomiting 3 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
   5.1 Nausea 3 1590 Risk Ratio (M-H, Fixed, 95% CI) 1.11 [0.95, 1.28]
   5.2 Vomiting 3 1589 Risk Ratio (M-H, Fixed, 95% CI) 1.25 [1.06, 1.47]
6 Maternal sleepiness 3 1590 Risk Ratio (M-H, Random, 95% CI) 0.55 [0.28, 1.07]
7 Assisted vaginal delivery 3 1266 Risk Ratio (M-H, Fixed, 95% CI) 1.00 [0.81, 1.22]
8 Caesarean section 3 1266 Risk Ratio (M-H, Random, 95% CI) 0.56 [0.16, 2.00]
9 Fetal heart rate changes (decelerations) 1 34 Risk Ratio (M-H, Fixed, 95% CI) 1.23 [0.92, 1.64]
10 Low Apgar score (≤ 7) at 1 and 5 minutes 4 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
   10.1 Low scores at 1 minute 4 662 Risk Ratio (M-H, Fixed, 95% CI) 0.76 [0.50, 1.13]
   10.2 Low scores at 5 minutes 3 616 Risk Ratio (M-H, Fixed, 95% CI) 0.50 [0.05, 5.37]
11 Naloxone administration 1 998 Risk Ratio (M-H, Fixed, 95% CI) 0.89 [0.77, 1.02]
   11.1 <36 weeks‐ gestation 1 23 Risk Ratio (M-H, Fixed, 95% CI) 0.96 [0.49, 1.89]
   11.2 ≥ 36 weeks‐ gestation 1 975 Risk Ratio (M-H, Fixed, 95% CI) 0.89 [0.77, 1.02]
12 Neonatal resuscitation 2 1356 Risk Ratio (M-H, Fixed, 95% CI) 1.00 [0.95, 1.05
   12.1 < 36 weeks‐ gestation 1 23 Risk Ratio (M-H, Fixed, 95% CI) 0.89 [0.69, 1.16]
   12.2 ≥ 36 weeks‐ gestation 2 1333 Risk Ratio (M-H, Fixed, 95% CI) 1.00 [0.95, 1.05]
13 Admission to NICU 1 199 Risk Ratio (M-H, Fixed, 95% CI) 0.88 [0.48, 1.63;]
14 Breastfeeding problems 1 197 Risk Ratio (M-H, Fixed, 95% CI) 0.76 [0.17, 3.30]
15 Apgar less than or equal to 7 at 1 minute 2 129 Risk Ratio (M-H, Fixed, 95% CI) 0.89 [0.47, 1.67]
16 Neonatal resuscitation 1 100 Risk Ratio (M-H, Fixed, 95% CI) 1.5 [0.26, 8.60]