Table 1.
Hypermethylated CpG islands at least partially within 500 bp of miRNAs in IDH1MUT versus IDH1/2WT gliomas (G-CIMP).
| miRNA ID | Associated CpG Island Location | RRBS Methylation | TCGA Gene Expression | TaqMan qPCR | ||||
|---|---|---|---|---|---|---|---|---|
| chr | Start-end | Diff. of Mean (WT-MUT) | P-value | Fold change (WT/MUT) | P-value | Fold change (WT/MUT) | P-value | |
| miR-148a | 7 | 25990012_25991320 | −0.24 | 1.30E-10 | 2.44 | 2.40E-09 | 4.50 | 1.26E-06 |
| miR-935 | 19 | 54485303_54486322 | −0.29 | 1.32E-05 | NA | NA | 1.90 | 0.481 |
| miR-137 | 1 | 98510966_98511710 | −0.38 | 6.52E-08 | 1.09 | 0.44 | 2.66 | 0.22 |
| miR-2682 | 1 | 98510966_98511710 | −0.38 | 6.52E-08 | NA | NA | NA | NA |
| miR-4520b | 17 | 6558221_6558441 | −0.61 | 1.23E-07 | NA | NA | NA | NA |
| miR-4520a | 17 | 6558221_6558441 | −0.61 | 1.23E-07 | NA | NA | NA | NA |
| miR-3131 | 2 | 219922154_219923130 | −0.32 | 1.79E-09 | NA | NA | Undetectable in all samples | -- |
| 219923669_219923911 | −0.30 | 3.18E-05 | ||||||
| miR-4710 | 14 | 105144247_105144503 | −0.42 | 4.60E-10 | NA | NA | 0.03 | 0.262 |
RRBS: Reduced Representative Bisulfite Sequencing; TCGA, The Cancer Genome Alta