Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanisms by which phosphorylation may affect drug efficacy. For Class 1 hits, phosphorylation inhibits (⊤) both drug binding and target activity, whereas for Class 2 hits, phosphorylation inhibits drug binding while activating (→) the target. While this schematic depicts phosphorylation inhibiting drug binding, it may in some cases enhance binding as discussed in the text.
