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. 2014 Sep 30;307(10):E928–E934. doi: 10.1152/ajpendo.00420.2014

Fig. 2.

Fig. 2.

Assessment of tissue-specific insulin actions by hyperinsulinemic-euglycemic clamps in mice with elevated endogenous growth hormone levels due to somatotrope-specific loss of IGF-I and insulin receptors (HiGH) and control mice, maintained on a chow diet. A: plasma insulin levels before and after hyperinsulinemic-euglycemic clamp. B and C: blood glucose (B) and GIR (C) during hyperinsulinemic-euglycemic clamp. D: tissue-specific Rg of GAS, VAS L, UG-fat, SOL, and HRT. E: ERa assessed by hyperinsulinemic-euglycemic clamp (n = 6–8 mice/group, 20 wk old). F: Pck1 expression of HiGH and control mice (20 wk old, LF fed, n = 5–7 mice/group). aSignificant difference between clamped and basal state within genotype (E). *P < 0.05 and **P < 0.01, significant difference between control and HiGH mice (D, E, and F).