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. 2014 Sep 3;112(10):2605–2615. doi: 10.1152/jn.00111.2014

Fig. 6.

Fig. 6.

A PLC activator potentiates the DHPG-enhanced DSI in neonates to the level of juveniles. Representative time course is shown of eIPSCs recorded from CA1 neurons in the presence of a PLC activator, m-3M3FBS (right, B, D, F, H) or its inactive analog, o-3M3FBS (left, A, C, E, G) in slices obtained from neonatal and juvenile rats, with or without DHPG coapplication as indicated. Traces below are representative averaged eIPSCs before and during bath application of the chemicals. I: histograms show that o-3M3FBS had no effect on basal DSI or the action of DHPG on DSI in either group (ANOVA, #P < 0.05; ##P < 0.01). m-3M3FBS significantly increased basal DSI in juveniles but not neonates (ANOVA, ##P < 0.01). When coapplied with DHPG, m-3M3FBS increased neonatal DSI to the juvenile level (ANOVA, #P < 0.05, ##P < 0.01); the juvenile level was not further enhanced by m-3M3FBS. All of the slices were preincubated with agatoxin. Calibration: continuous traces = 1 nA, 1 min; mean traces = 1 nA, 100 ms.