Fig. 3.

Splenic CD4⁺ forkhead box protein 3 (FoxP3)⁺ regulatory T cells (T_reg) from FoxP3^GFP/B6 mice [wild-type (WT) T_reg] successfully suppresses CD8 T cell activation. (a) Frequency of effector memory (CD44⁺ CD62L^–) subpopulations in CD8 T cell subsets in liver and the periphery. (b) Absolute number of intra-hepatic mononuclear cells (MNCs), CD8 T cells, and effector memory (CD44⁺CD62L^–) subpopulations in CD8 T cell subsets. dnRII CD8 group (n = 11), dnRII CD8 ⁺ dnRII T_reg group (n = 7) and dnRII CD8 ⁺ WT T_reg group (n = 7). Data are expressed as mean ± standard error of the mean. *P < 0·05; **P < 0·01; ***P < 0·001; two-tailed unpaired t-test.