Table 3.

Frequencies of interleukin (IL)-10 (−1082,−819,−592) genotypes and alleles in patients and control subjects

Genotypes and alleles	Control group n (%)	Patient group n (%)	OR (95% CI)	P-value	P′
IL-10 −1082
Co-dominant
A/A	53 (44·2%)	41 (34·2%)
G/A	43 (35·8%)	49 (40·8%)	1·47 (0·83–2·63)	0·2430
G/G	24 (20%)	30 (25%)	1·62 (0·82–3·17)	0·27	0·44
Dominant
A/A	53 (44·2%)	41 (34·2%)
G/A + G/G	67 (55·8%)	79 (65·8%)	1·52 (0·90–2·57)	0·11
Recessive
A/A + G/A	96 (80%)	90 (75%)
G/G	24 (20%)	30 (25%)	1·33 (0·73–2·45)	0·35
Over-dominant
A/A + G/G	77 (64·2%)	71 (59·2%)
G/A	43 (35·8%)	49 (40·8%)	1·24 (0·73–2·08)	0·43
Alleles
G	149	131
A	93	109	0·734 (0·51–1·056)	0·11
IL-10 −819
Co-dominant
C/C	25 (20·8%)	57 (47·5%)
C/T	58 (48·3%)	34 (28·3%)	0·26 (0·14–0·48)	0·00003476**
T/T	37 (30·8%)	29 (24·2%)	0·34 (0·17–0·68)	<0·0001**	0·00014**
Dominant
C/C	25 (20·8%)	57 (47·5%)
C/T + T/T	95 (79·2%)	63 (52·5%)	0·29 (0·16–0·51)	<0·0001**
Recessive
C/C + C/T	83 (69·2%)	91 (75·8%)
T/T	37 (30·8%)	29 (24·2%)	0·71 (0·40–1·26)	0·25
Over-dominant
C/C + T/T	62 (51·7%)	86 (71·7%)
C/T	58 (48·3%)	34 (28·3%)	0·42 (0·25–0·72)	0·0014**
Alleles
C	148	108
T	92	132	1·96 (1·37–2·829)	0·0003**
IL-10 −592
Co-dominant
A/A	54 (45%)	29 (24·2%)
C/A	41 (34·2%)	60 (50%)	2·72 (1·49–4·97)	0·001598**
C/C	25 (20·8%)	31 (25·8%)	2·31 (1·15–4·62)	0·0026**	0·057*
Dominant
A/A	66 (55%)	91 (75·8%)
C/A + C/C	95 (79·2%)	89 (74·2%)	2·57 (1·48–4·46)	0·00006**
Recessive
A/A + C/A	95 (79·2%)	89 (74·2%)
C/C	25 (20·8%)	31 (25·8%)	1·32 (0·73–2·41)	0·36
Over-dominant
A/A + C/C	79 (65·8%)	60 (50%)
C/A	41 (34·2%)	60 (50%)	1·93 (1·15–3·24)	0·013*
Alleles
A	149	118
C	91	122	1·693 (1·177–2·435)	0·0058**

^*P value < 0·05;

^**P value < 0·01; P′ after Bonferroni correction.

OR = odds ratio; CI = confidence interval.