TABLE III.
COX PROPORTIONAL HAZARD MODELS SHOWING INCIDENCE OF CVD EVENTS IN SHS 10-YEAR FOLLOW UP, BY CATEGORY OF BASELINE KIDNEY FUNCTION
| eGFR ≥90, number (event %) | eGFR 60–89, number (event %) HR (95% CI) |
eGFR 30–59, number (event %) HR (95% CI) |
eGFR <30, number (event %) HR (95% CI) |
|
|---|---|---|---|---|
| Diabetes-adjusted analysis | ||||
| MDRD | 268 (18.93) | 464 (19.74) | 122 (32.11) | 24 (40.86) |
| 1.0 | 1.12 (0.97–1.30) | 2.08 (1.68–2.56)* | 4.10 (2.70–6.22)* | |
| CG | 398 (17.91) | 366 (22.14) | 94 (34.56) | 16 (37.21) |
| 1.0 | 1.45 (1.26–1.67)* | 2.89 (2.31–3.62)* | 4.26 (2.58–7.02)* | |
| Multivariate adjusted analysis† | ||||
| MDRD | 268 (18.93) | 464 (19.74) | 122 (32.11) | 24 (40.86) |
| 1.0 | 1.08 (0.93–1.26) | 1.84 (1.47–2.32)* | 3.87 (2.54–5.88)* | |
| CG | 398 (17.91) | 366 (22.14) | 94 (34.56) | 16 (37.21) |
| 1.0 | 1.12 (0.96–1.31) | 2.01 (1.56–2.59)* | 3.77 (2.29–6.23)* | |
CG = Cockcroft-Gault equation; CVD = cardiovascular disease; eGFR = estimated glomerular filtration rate; HR = hazard ratio; MDRD = Modification of Diet in Renal Disease study equation; 95% CI = 95% confidence interval; SHS = Strong Heart Study.
*
Significant at the 5% level of significance.
†
Adjusted for diabetes, age and sex.