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Serum levels of atherogenic inflammatory factors decreased in OCN-treated compared with vehicle-treated ApoE-KO mice. (A) TNF-α (B) IL-1α (C) IL-12 p70 (D) IL-12 p40. Data were shown as mean ± SEM, 6 to 8 mice per group were analyzed. **P < 0.01 vehicle-treated mice fed with HFD vs. vehicle-treated mice fed with chow diet; #P < 0.05, ##P < 0.01 OCN-treated mice fed with HFD vs. vehicle-treated mice fed with HFD. HF, high fat diet; CD, chow diet; OCN, osteocalcin.
