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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Neurol Clin. 2014 Aug;32(3):569–vii. doi: 10.1016/j.ncl.2014.04.008

BOX 21. PATTERN 10 STIFFNESS/DECREASED ABILITY TO RELAX.

  • Improves with exercise

    • Myotonia – Na++ or Cl- channelopathy

  • Worsens with exercise/cold sensentivity

    • Paramyotonia – Na++ channelopathy

    • Brody’s disease

  • With fixed weakness

    • Myotonic dystrophy (DM 1)

    • Proximal myotonic myopathy (DM 2)

    • Becker’s disease (AR Cl- channelopathy)

  • Other:

    • Malignant hyperthermia

    • Neuromyotonia

    • Rippling muscle

    • Stiff-person syndrome