BOX 25. UTILITY OF MUSCLE BIOPSY STAINS AND HISTOCHEMICAL REACTIONS.

Histochemical Reactions and Stains	Clinical Utility
ATPase	Distribution of fiber types
Gomori Trichrome	General histology and mitochondrial disease
Hematoxylin and Eosin	General histology
NADH, SDH, cytochrome oxidase	Myofibrillar and mitochondrial abnormalities
Oil Red O	Lipid storage diseases
Periodic acid-Schiff	Glycogen storage diseases
Congo Red, Crystal Violet	Detection of amyloid deposition
Myophosphorylase	McArdle’s disease
Phosphofructokinase	Phosphofructokinase deficiency
Myoadenylate deaminase	Myoadenylate deaminase deficiency
Dystrophin immunostain	Duchenne’s and Becker’s muscular dystrophy
Dysferlin immunostain	Limb Girdle MD 2B

Membrane attack complex immunostain Dermatomyositis