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FGFR2 kinase domains harboring melanoma mutations have reduced tyrosine autophosphorylation activity. Wild-type FGFR2K and four mutant FGFR2Ks, each harboring E475K, D530N, I642V, or A648T single mutation, are subjected to in vitro kinase assays. Columns, average of three independent experiments; bars, SD. The tyrosine autophosphorylation activities of these wild-type and mutant FGFR2Ks were determined using a continuous spectrophotometric assay as previously described (43).
