Table 1.

Summary of Melanoma Samples Carrying FGFR2 Mutations

Samples	Nucleotide Change	Codon Change	BRAF	NRAS
Cell Lines
MM540	G812A	G271E	V600E	wt
UACC1940	G913A	G305R	wt	wt
WSB	C1109G	T370R*	V600E	wt
M92-001†	G1423A	E475K*	wt	G13R
ME10538†	G1423A	E475K	V600E	wt
M91-054	T2308G	L770V	V600E	wt
UACC2534	G752A	R251Q	wt	wt
A375	G1906A	E636K*	V600E	wt
UACC3093	GG2100-1AA	G701S	wt	Q61L
D11	G1920A	M640I	wt	Q61L
MM369	G655A	E219K	V600E	wt
D22	G1588A	D530N	wt	wt
D22	C2275T	R759X	wt	wt
MM229	G2276A	R759Q	L597S	wt
A04	G1942A	A648T*	wt	wt
A05	A479C	E160A	V600E	wt
Metastatic Tumors
Met19	G680A	G227E	wt	nd
Met27	C71T	S24F	nd	nd
Met15	G229A G1720A C2063T C2122T	V77M E574K S688F P708S	V600E	nd
Primary Tumors
81‡	IVS15-2A>T§	FS	V600E	wt
AM169‖	T743A	V248D	wt	wt
AM146¶	C637T	H213Y	wt	Q61L
53**	G1422A	W474X	wt	wt
71**	G1924A	I642V	wt	wt

Abbreviations: wt, wild type; nd, not done.

^*Samples were homozygous for this mutation.

^†Microsatellite genotyping confirmed that these cell lines were independent.

^‡Superficial spreading primary melanoma, no chronic sun damage evident.

^§The IVS15_2A>T is predicted to result in the skipping of exon 16, subsequent frameshift for 27 amino acids, and a premature truncation at codon 690 in the kinase domain.

^‖Acral melanoma, histologically superficial spreading melanoma.

^¶Mucosal primary melanoma.

^**Primary Lentigo Maligna Melanoma, with histologic evidence of chronic sun damage.