Table 1.

Components of our linking model between individual case reporting and the real world

Variable	Type of entities being counted	Context
$$N_x^R$$	Reports on X	Database
$$N_{\mathit{\text{xy}}}^R$$	Reports on X together with Y	Database
$$N_x^A$$	Adverse episodes that follow exposure to X	Real world
$$N_{\mathit{\text{xy}}}^A$$	Adverse episodes that follow exposure to X and that include Y	Real world
$$N_x^E$$	Exposures to X	Real world
$$N_{\mathit{\text{xy}}}^E$$	Exposures to X followed by at least one adverse episode that includes Y	Real world

X and Y are the drug and adverse event of interest, respectively.