Table 1.

Striatal, caudate, and putamen BP_ND from manual SPECT, CT-guided, and MRI-guided ROIs methods; the intra- and interobserver concordance correlation coefficients, Bland-Altman biases, and limits of agreement of manual SPECT and CT-guided ROI methods.

	Striatal BPND	Caudate BPND	Putamen BPND
Manual SPECT ROI
Intraobserver (observer A)
First analysis	0.46 ± 0.24	0.55 ± 0.26	0.42 ± 0.24
Second analysis	0.48 ± 0.26	0.58 ± 0.29	0.38 ± 0.26
CCC	0.96	0.96	0.93
95% CI of CCC	0.93–0.98	0.94–0.98	0.89–0.96
Bias (mean difference)	−0.03	−0.03	0.03
Limits of agreement	−0.16, 0.10	−0.16, 0.11	−0.13, 0.20
Interobserver*
Observer B analysis	0.39 ± 0.23	0.48 ± 0.22	0.36 ± 0.24
CCC	0.89	0.89	0.88
95% CI of CCC	0.82–0.93	0.83–0.93	0.80–0.93
Bias (mean difference)	0.07	0.07	0.05
Limits of agreement	−0.11, 0.25	−0.11, 0.25	−0.16, 0.27
CT-guided ROI
Intraobserver (observer A)
First analysis	0.49 ± 0.25	0.54 ± 0.25	0.46 ± 0.27
Second analysis	0.48 ± 0.25	0.52 ± 0.26	0.46 ± 0.27
CCC	0.98	0.97	0.97
95% CI of CCC	0.97–0.99	0.94–0.98	0.95–0.98
Bias (mean difference)	0.01	0.02	0.01
Limits of agreement	−0.08, 0.11	−0.11, 0.14	−0.12, 0.13
Interobserver*
Observer B analysis	0.48 ± 0.26	0.56 ± 0.27	0.45 ± 0.28
CCC	0.97	0.95	0.96
95% CI of CCC	0.95–0.98	0.92–0.97	0.94–0.98
Bias (mean difference)	0.01	−0.02	0.02
Limits of agreement	−0.12, 0.13	−0.18, 0.13	−0.13, 0.16
MRI-guided ROI	0.46 ± 0.25	0.53 ± 0.26	0.43 ± 0.25

BP_ND: nondisplaceable binding potential; SPECT: single photon emission computed tomography; ROI: region of interest; CCC: concordance correlation coefficient; CI: confidence interval; CT: computed tomography

^*Interobserver analysis was compared with observer A's first analysis.