Table 2.

Associations of single-nucleotide polymorphisms (SNPs) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (GPA⁺ MPA), According to Cohort.

				Combined cohort (N = 2267 case patients, 6858 controls)
Gene	Chromosome	SNP (Minor Allele)	Nucleotide change	OR	P-value
SNPs WITH GENOME-WIDE SIGNIFICANCE IN COMBINED COHORT
HLA-DP	6	rs3117242	A > G	3.67	1.5 × 10−71
HLA-DQ	6	rs5000634	A > G	0.80	2.9 × 10−9
COL11A2	6	rs3130233	A > G	1.51	7.8 × 10−15
COL11A2	6	rs3117016	A > G	1.83	6.4 × 10−24
SERPINA1	14	rs7151526	A > C	0.59	2.4 × 10−9
				Clinical syndrome
				GPA vs. control (N = 1683 vs. 6858)	MPA vs. control (N = 489 vs. 6858)
Gene	Chromosome	SNP	Nucleotide change	OR	P-value
ASSOCIATIONS OF SNPs AND ANCA – ASSOCIATED VASCULITIS, ACCORDING TO CLINICAL AND ANCA SUBGROUPS
HLA-DP	6	rs3117242	A > G	5.39	3.1 × 10−85
HLA-DQ	6	rs5000634	A > G	0.83	2.2 × 10−6
ARHGAP18	6	rs1705767	A > C	0.78	3.3 × 10−7
SERPINA1	14	rs7151526	A > C	0.54	4.4 × 10−10
PRTN3	19	rs62132295	A > G	0.78	2.6 × 10−5
MOSPD2	X	rs6628825	A > G	0.80	2.6 × 10−6

				ANCA specificity
				Proteinase 3 vs. control (N = 1521 vs. 6858)		Myeloperoxidase vs. control (N = 556 vs. 6858)
Gene	Chromosome	SNP	Nucleotide change	OR	P-value	OR	P-value
HLA-DP	6	rs3117242	A > G	7.03	6.2 × 10−89	1.55	3.2 × 10−2
HLA-DQ	6	rs5000634	A > G	0.86	3.3 × 10−5	0.65	2.1 × 10−8
ARHGAP18	6	rs1705767	A > C	0.73	5.2 × 10−8	0.87	1.0 × 10−2
SERPINA1	14	rs7151526	A > C	0.53	5.6 × 10−12	0.84	2.8 × 10−1
PRTN3	19	rs62132295	A > G	0.73	2.6 × 10−7	1.10	2.2 × 10−1
MOSPD2	X	rs6628825	A > G	0.77	6.1 × 10−7	0.86	6.3 × 10−1

GPA, granulomatosis with poliangiitis, MPA, microscopic poliangiitis, EGPA, eosinophilic granulomatosis with poliangiitis.