Table 2.
First incident cardiovascular events during follow-up in study to determine lifetime risk of cardiovascular disease and its first manifestation. Values are numbers of participants (percentage) unless stated otherwise
| Total (n=8419) | Rotterdam Study I (n=6045) | Rotterdam Study II (n=2374) | ||||
|---|---|---|---|---|---|---|
| Men (n=2287) | Women (n=3758) | Men (n=1006) | Women (n=1368) | |||
| First incident event | ||||||
| Cardiovascular disease event | 2888 (34.3) | 1053 (46.0) | 1491 (39.7) | 164 (16.3) | 180 (13.2) | |
| Coronary heart disease | 826 (9.8) | 361 (15.8) | 338 (9.0) | 81 (8.1) | 46 (3.4) | |
| Myocardial infarction | 417 (5.0) | 188 (8.2) | 157 (4.2) | 44 (4.4) | 28 (2.0) | |
| Coronary revascularisation | 164 (1.9) | 81 (3.5) | 46 (1.2) | 25 (2.5) | 12 (0.9) | |
| Coronary artery bypass grafting | 80 (1.0) | 44 (1.9) | 17 (0.5) | 13 (1.3) | 6 (0.4) | |
| Percutaneous coronary intervention | 84 (1.0) | 37 (1.6) | 29 (0.8) | 12 (1.2) | 6 (0.4) | |
| Other fatal coronary heart disease | 245 (2.9) | 92 (4.0) | 135 (3.6) | 12 (1.2) | 6 (0.4) | |
| Cerebrovascular disease | 1198 (14.2) | 382 (16.7) | 674 (17.9) | 44 (4.4) | 98 (7.2) | |
| Stroke | 725 (8.6) | 231 (10.1) | 416 (11.1) | 23 (2.3) | 55 (4.0) | |
| Ischaemic stroke | 396 (4.7) | 133 (5.8) | 213 (5.7) | 17 (1.7) | 33 (2.4) | |
| Haemorrhagic stroke | 72 (0.9) | 25 (1.1) | 35 (0.9) | 2 (0.2) | 10 (0.7) | |
| Unspecified stroke | 257 (3.1) | 73 (3.2) | 168 (4.5) | 4 (0.4) | 12 (0.9) | |
| Transient ischaemic attack | 470 (5.6) | 151 (6.6) | 256 (6.8) | 20 (2.0) | 43 (3.1) | |
| Carotid revascularisation | 3 (0.0) | 0 (0.0) | 2 (0.1) | 1 (0.1) | 0 (0.0) | |
| Heart failure | 762 (9.1) | 267 (11.7) | 430 (11.4) | 37 (3.7) | 28 (2.0) | |
| Other cardiovascular death | 102 (1.2) | 43 (1.9) | 49 (1.3) | 2 (0.2) | 8 (0.6) | |
| Non-cardiovascular death | 1532 (18.2) | 573 (25.1) | 791 (21.0) | 93 (9.2) | 75 (5.5) | |
| No event (censored alive) | 3999 (47.5) | 661 (28.9) | 1476 (39.3) | 749 (74.5) | 1113 (81.4) | |
| Follow-up time | ||||||
| Total person time (person years) | 81 276 | 22 769 | 42 234 | 6709 | 9564 | |
| Median (IQR) (years) | 8.6 (5.9 to 14.9) | 10.5 (4.8 to 15.3) | 13.2 (6.2 to 16.0) | 7.2 (5.9 to 8.3) | 7.4 (6.3 to 8.4) | |
| Median (IQR) for participants censored alive (years) | 13.5 (7.7 to 16.2) | 16.0 (15.1 to 16.7) | 16.2(15.2 to 17.1) | 7.7 (6.8 to 8.4) | 7.7 (6.7 to 8.4) | |
IQR=interquartile range.