Table 4.

 Hazard ratios (95% confidence intervals) for risk of first incident cardiovascular disease event and non-cardiovascular death for women compared with men (reference category). All regression analyses used follow-up time as time scale and were stratified on cohort (see appendix table C for results per cohort)

	Traditional Cox model	Competing risks model*
Model 1 (unadjusted)
Cardiovascular disease	0.75 (0.70 to 0.81)	0.81 (0.76 to 0.88)
Coronary heart disease†	0.48 (0.42 to 0.55)	0.52 (0.46 to 0.60)
Cerebrovascular disease‡	0.99 (0.88 to 1.12)	1.15 (1.02 to 1.29)
Heart failure	0.83 (0.72 to 0.96)	0.95 (0.82 to 1.09)
Other cardiovascular death§	0.67 (0.45 to 1.00)	0.79 (0.53 to 1.17)
Non-cardiovascular death	0.68 (0.61 to 0.75)	0.78 (0.71 to 0.86)
Model 2¶
Cardiovascular disease	0.62 (0.57 to 0.67)	0.73 (0.67 to 0.79)
Coronary heart disease†	0.42 (0.37 to 0.49)	0.50 (0.43 to 0.58)
Cerebrovascular disease‡	0.83 (0.73 to 0.93)	1.06 (0.94 to 1.20)
Heart failure	0.62 (0.53 to 0.72)	0.79 (0.68 to 0.93)
Other cardiovascular death§	0.53 (0.35 to 0.80)	0.72 (0.48 to 1.09)
Non-cardiovascular death	0.51 (0.46 to 0.57)	0.67 (0.60 to 0.74)
Model 3**
Cardiovascular disease	0.68 (0.62 to 0.75)	0.76 (0.69 to 0.83)
Coronary heart disease†	0.45 (0.37 to 0.53)	0.51 (0.43 to 0.60)
Cerebrovascular disease‡	0.96 (0.83 to 1.11)	1.16 (1.00 to 1.33)
Heart failure	0.62 (0.52 to 0.75)	0.73 (0.61 to 0.88)
Other cardiovascular death§	0.73 (0.44 to 1.19)	0.96 (0.61 to 1.50)
Non-cardiovascular death	0.63 (0.55 to 0.71)	0.76 (0.66 to 0.87)

*Fine and Gray method for subdistribution regression with competing risks.²⁰

†Coronary heart disease=myocardial infarction, coronary revascularisation, or death due to coronary heart disease.

‡Cerebrovascular disease=stroke, transient ischaemic attack, or carotid revascularisation.

§Other cardiovascular death=all cardiovascular mortality other than fatal coronary heart disease or stroke.

¶Adjusted for age (linear covariate) and level of education.

**Adjusted for age (linear covariate), level of education, systolic and diastolic blood pressure, concentrations of total and high-density lipoprotein cholesterol, diabetes mellitus, smoking status, family history of premature myocardial infarction, body mass index, concentration of C-reactive protein, use of drugs to lower blood pressure, and use of statins.