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. 2014 Oct 21;5:360. doi: 10.3389/fgene.2014.00360

FIGURE 2.

FIGURE 2

FMRP expression in AD model APP/PS1 mice. (A) Cortical and subcortical, and cerebellar lysates from 80-week-old APP/PS1 (n = 6) and age-matched controls (n = 8) probed with the 17722 α-FMRP antibody and actin or tubulin. (A1) FMRP/actin values were calculated and normalized to WT levels, and expressed as %WT in the quantification. Results are the summary of values calculated in technical triplicate. (B) Eight-week-old APP/PS1 (n = 3) and WT littermate controls (n = 3) were compared for FMRP expression in cortical and subcortical and cerebellar lysates. (B1) FMRP/tubulin values are expressed as %WT, and data are the summary of experiments performed in technical triplicate. (C) Eight-week-old WT (n = 3) and 80-week-old WT (n = 8) cortical and cerebellar lysates compared for FMRP expression. (C1) FMRP/tubulin values are expressed as percentage of mean 8-week-old samples, and data are the summary of experiments performed in duplicate. (D) Hippocampal FMRP expression using the 1C3 α-FMRP antibody in WT and APP/PS1 mice. (E) Cortical FMRP in the same mice as in (D).