Table 5.
Quantitative traits stratified according to ADAM10 genotypes in case and control group
| Characteristics | Case group genotype | Control group genotype | P value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs653765 | CC | CT | TT | CC | CT | TT | P CC | P CC * | P CT | P CT * | P TT | P TT * |
| Blood glucose (mmol/L) | 5.84 ± 2.39 | 5.79 ± 2.41 | 8.33 ± 4.07 | 5.30 ± 1.34 | 5.71 ± 2.19 | 5.75 ± 1.76 | 0.003 | 0.009 | 0.083 | 0.083 | 0.08 | 0.12 |
| Total cholesterol (mg/dL) | 5.12 ± 0.97 | 5.11 ± 1.62 | 5.03 ± 0.79 | 4.48 ± 1.07 | 4.82 ± 1.06 | 4.56 ± 1.57 | <0.001 | <0.001 | 0.098 | 0.147 | 0.408 | 0.408 |
| Triglycerides (mmol/L) | 1.60 ± 0.95 | 1.51 ± 1.01 | 1.56 ± 0.67 | 1.58 ± 1.51 | 1.56 ± 1.04 | 1.52 ± 1.01 | 0.853 | 0.919 | 0.751 | 0.919 | 0.919 | 0.919 |
| HDL (mmol/L) | 1.27 ± 0.54 | 1.28 ± 0.32 | 1.48 ± 0.38 | 1.60 ± 0.40 | 1.52 ± 0.37 | 1.60 ± 0.46 | <0.001 | <0.001 | <0.001 | <0.001 | 0.054 | 0.054 |
| LDL (mmol/L) | 2.79 ± 0.88 | 2.8 ± 0.89 | 2.65 ± 1.20 | 2.89 ± 0.87 | 2.87 ± 1.10 | 2.84 ± 0.70 | 0.193 | 0.579 | 0.63 | 0.945 | 0.665 | 0.665 |
| rs514049 | AA | CA | CC | AA | CA | CC | P AA | P AA * | P CA | P CA * | P CC | P CC * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood glucose (mmol/L) | 5.90 ± 2.48 | 6.12 ± 2.66 | 4.95 ± 0.14 | 5.37 ± 1.52 | 5.62 ± 2.01 | 6.61 ± 1.46 | 0.003 | 0.009 | 0.381 | 0.381 | 0.123 | 0.185 |
| Total cholesterol (mg/dL) | 5.16 ± 1.02 | 5.07 ± 1.93 | 5.43 ± 0.34 | 4.79 ± 1.07 | 4.77 ± 1.18 | 4.00 ± 1.22 | <0.001 | <0.001 | 0.242 | 0.242 | 0.219 | 0.329 |
| Triglycerides (mmol/L) | 1.56 ± 0.93 | 1.64 ± 1.17 | 1.29 ± −0.80 | 1.56 ± 1.43 | 1.73 ± 1.28 | 1.66 ± 0.71 | 0.944 | 0.944 | 0.731 | 0.944 | 0.635 | 0.944 |
| HDL (mmol/L) | 1.28 ± 0.50 | 1.25 ± 0.32 | 1.27 ± 0.32 | 1.59 ± 0.41 | 1.50 ± 0.35 | 1.86 ± 0.48 | <0.001 | <0.001 | 0.004 | 0.006 | 0.185 | 0.185 |
| LDL (mmol/L) | 2.80 ± 0.88 | 2.75 ± 0.97 | 2.16 ± 0.87 | 2.87 ± 0.95 | 2.87 ± 0.90 | 2.82 ± 1.14 | 0.206 | 0.618 | 0.6 | 0.6 | 0.514 | 0.771 |
HDL, high‐density lipoprotein; LDL, low‐density lipoprotein.
Continuous data are expressed as the means ± SD.
PCC: P value of CC genotype between case group and control group; PCT: P value of CT genotype between case group and control group; PTT: P value of TT genotype between case group and control group; PAA: P value of AA genotype between case group and control group; PCA: P value of CA genotype between case group and control group.
Adjusted for age, sex, hypertension, diabetes mellitus, hyperlipidemia, and smoking.
*False discovery rate‐adjusted P value for multiple hypotheses testing using the Benjamini–Hochberg method.