FIGURE 2.

Cocaine exposure during adolescence simplifies oPFC dendrite arbors in adulthood. (A) Representative deep-layer oPFC pyramidal neurons are shown. Terminal branches are indicated by red brackets. (B) Total dendrite length in the apical tree was not significantly affected, but basal lengths were reduced. (C) Simultaneously, dendritic arbors on the basal tree were simplified, as indicated by fewer Sholl intersections 40–100 µm from the soma. (D) The total length of basal terminal branches did not significantly differ between groups, consistent with arbor simplification in relatively close proximity to the soma in (C). (E) Sholl intersections for apical arbors did not differ. Means + SEMs. *p < 0.05 vs. saline, **p < 0.05 for 40–100 µm from the soma.