Table 1.
Number of births by participating country, with proportion (%) from multiple births, and number of Down syndrome (DS) cases from singleton and multiple births, 1990–99 and 2000–2009
| Country | Years | 1990–99 | 2000–2009 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Births n | Multiple births % | DS cases from singleton births n | DS cases from multiple births n | Births n | Multiple births % | DS cases from singleton births n | DS cases from multiple births n | ||
| Poland (Wielkopolska) | 2000–2007 | – | – | – | – | 274 658 | 2.27 | 404 | 10 |
| Malta | 1999–2007 | 4376 | 3.15 | 11 | 0 | 30 896 | 2.78 | 59 | 3 |
| Austria (Styria)* | 1990–2007 | 125 787 | 2.30 | 179 | 3 | 80 706 | 3.00 | 152 | 5 |
| England and Wales (NDSCR) | 1990–2009 | 6 666 234 | 2.66 | 12 102 | 245 | 6 315 113 | 3.02 | 15 037 | 318 |
| Ireland*,† | 1990–2007 | 240 092 | 2.51 | 514 | 13 | 269 918 | 3.03 | 621 | 16 |
| Switzerland (Vaud) | 1990–2007 | 76 975 | 2.60 | 179 | 5 | 55 848 | 3.15 | 189 | 3 |
| France (Paris)** | 1990–2007 | 371 437 | 3.63 | 1 125 | 40 | 216 558 | 3.62 | 865 | 14 |
| Denmark (Odense)* | 1990–2007 | 57 949 | 3.52 | 91 | 4 | 40 558 | 4.68 | 92 | 3 |
| Total | 1990–2009 | 7 542 850 | 2.71 | 14 201 | 310 | 7 284 255 | 3.02 | 17 419 | 372 |
Denominators available by 5-year data on maternal age but NOT by like and unlike sex so monozygotic and dizygotic denominators were extrapolated from proportions in other EUROCAT Registries.
The Parisian registry was able to provide denominator data by 5 years of maternal age for all years but by like and unlike sex for 1993, 1997, 2001 and 2005 only, the proportions were extrapolated to other years within 4-year bands when estimating monozygotic and dizygotic denominators.
There are three Irish registries: Dublin (1990–2007) Cork and Kerry (1996–2004) and South east Ireland (1997–2007) All other countries have one participating EUROCAT registry.