Table 3.
Coronary Heart Disease (CHD) Events, Cardiovascular Disease (CVD) Events, CVD Mortality, and All-Cause Mortality According to Sarcopenic Obesity Groups (Defined According to Fat Mass Index (FMI) and Fat-Free Mass Index (FFMI))
| Sarcopenic Obesity Groupsa | P-Value (sarcopenia x Obesity Interaction) | |||||
|---|---|---|---|---|---|---|
| Optimal | Sarcopenic | Obese | Sarcopenic Obese | |||
| HR | HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| Total, n (%) | 1670 (41.3) | 1190 (29.4) | 756 (18.7) | 429 (10.6) | ||
| CHD events (n = 450) | Model 1 | 1.00 | 1.17 (0.94–1.46) | 1.13 (0.87–1.48) | 1.35 (1.00–1.83)b | .92 |
| Model 2 | 1.00 | 1.15 (0.91–1.45) | 1.04 (0.79–1.38) | 1.13 (0.82–1.56) | .79 | |
| CVD events (n = 827) | Model 1 | 1.00 | 1.05 (0.89–1.24) | 1.10 (0.90–1.33) | 1.21 (0.97–1.51) | .77 |
| Model 2 | 1.00 | 1.03 (0.87–1.22) | 1.01 (0.82–1.24) | 1.01 (0.79–1.29) | .85 | |
| CVD mortality (n = 502) | Model 1 | 1.00 | 1.18 (0.95–1.46) | 1.43 (1.12–1.82)b | 1.37 (1.02–1.82)b | .29 |
| Model 2 | 1.00 | 1.11 (0.89–1.39) | 1.25 (0.96–1.62) | 1.11 (0.81–1.53) | .30 | |
| All-cause mortality (n = 1288) | Model 1 | 1.00 | 1.19 (1.05–1.36)b | 1.26 (1.08–1.47)b | 1.18 (0.98–1.42) | .05 |
| Model 2 | 1.00 | 1.08 (0.94–1.24) | 1.09 (0.92–1.27) | 0.98 (0.80–1.20) | .19 | |
CHD = Coronary Heart Disease; CVD = Cardiovascular Disease; FFMI = Fat-Free Mass Index; FMI = Fat Mass Index; HR = Hazard Ratio. Model 1: adjusted for age. Model 2: adjusted for model 1 + smoking, alcohol, occupational social class, physical activity.
Cutoff for obesity (FMI > 28.7th percentile) corresponds to the WC > 102cm cutoff. Optimal (FMI ≤ 11.1 kg/m2, FFMI > 16.7 kg/m2); sarcopenic (FMI ≤ 11.1 kg/m2, FFMI ≤ 16.7 kg/m2); obese (FMI > 11.1 kg/m2, FFMI > 16.7 kg/m2); sarcopenic obese (FMI > 11.1 kg/m2, FFMI ≤ 16.7 kg/m2)
P < .05.