Table 2.
Gene signatures for classification of intrinsic CRC subtypes
| A-type | B-type | C-type | ||||
|---|---|---|---|---|---|---|
| HSPA4L | BG114486 | VAPB | THBS2 | GPSM1 | LOC338328 | ASPM |
| SLC7A11 | THC2669157 | HNRNPA1L2 | SPOCK1 | VWF | ANKRD35 | ORC6L |
| NUDT6 | QPRT | KIF3B | COL5A2 | WISP1 | KIAA1442 | ZNF367 |
| ME1 | PLA2G12B | ARFGEF2 | FBLN1 | SLIT3 | THY1 | NIPSNAP1 |
| DLG7 | VAV3 | PIWIL2 | MGP | MC1R | FES | SPBC25 |
| KNTC2 | PTPRO | FANCF | MXRA8 | LAMB2 | PGF | DIAPH3 |
| PRC1 | RNF43 | THC2644861 | DCN | PCOLCE | MAP3K3 | |
| ECHS1 | DDC | MOCS3 | AEBP1 | GPX7 | GPSM3 | |
| DEPDC1 | AXIN2 | PIGU | BASP1 | COX7A1 | NPC2 | |
| ACADSB | C13orf18 | CEP250 | COL6A1 | FGFR1 | C14orf139 | |
| EIF4A2 | TSPAN6 | IFT52 | COL1A2 | AK021531 | THC2532155 | |
| MREG | GGH | CXorf56 | HTRA1 | CALD1 | C1orf198 | |
| NIPA1 | PLAGL2 | COBLL1 | LOXL1 | JAK3 | FLT4 | |
| TIAL1 | ACSL6 | EPOR | COL5A1 | TRO | SNRP70 | |
| URM1 | RBP2 | MAPRE2 | FSTL1 | TGFB3 | KIAA1602 | |
| ZNF167 | SLC6A4 | SLC41A1 | RARRES2 | C1QTNF6 | ELMO1 | |
| RARA | CTSL2 | KCTD1 | MSN | DTX3 | RNF207 | |
| SNX21 | AMACR | TRIB2 | SPARC | NID2 | POLE | |
| NRXN2 | POFUT1 | PLK2 | PDGFRB | COL18A1 | CPSF6 | |
| ARFGAP1 | CEBPA | RAMP1 | TUBB6 | SLC27A1 | BCL2L14 | |
| PAPLN | PARD6B | LOC388610 | SERPINF1 | JAM2 | TOM1L1 | |
| SMARCC2 | PRDX5 | TPM2 | EFHA2 | SNRPC | ||
| AS3MT | SEPHS2 | CD248 | GGTLA1 | SYNCRIP | ||
| DKFZp547K054 | C20orf142 | LGALS1 | LAMC1 | NDUFAB1 | ||
| RGN | GPSM2 | CRYAB | ROBO4 | RABL3 | ||
| CTSF | SLC5A6 | CXCL12 | IGFBP5 | XRCC2 | ||
| SORBS1 | TP53RK | CLDN5 | FAM20C | NDUFA10 | ||
| FCGRT | NCOA6 | LOC387763 | TSPYL5 | PA2G4 | ||
| LARP6 | C20orf111 | BNC2 | VAMP5 | RFC4 | ||
| FHOD3 | C20orf43 | OBSL1 | FBXO17 | ZNF695 | ||
| NINL | HNF4A | EVL | CLEC11A | PPARA | ||
| SRPX2 | PSMA7 | COL6A3 | PDLIM4 | FBXO5 | ||
Gene signatures specific for each of the three CRC intrinsic subtypes. Genes of each of the subtype profile (A-type 32 genes, B-type 53 genes and C-type 102 genes) are ranked (top to bottom and left to right) according to their relative up-regulation (green) or down-regulation (blue) compared to the other two subtypes.