Table 11.

NCCN and European LeukemiaNet Response Criteria for Patients With Chronic-Phase Chronic Myelogenous Leukemia

	NCCN		European LeukemiaNet80
Evaluation Time (mo)	Optimal Response	Failure	Optimal Response	Suboptimal Response	Failure
3	CHR	Less than CHR	CHR and at least an mCyR	No CCyR	Less than CHR
6	CCyR or PCyR	No CyR	At least a PCyR	Less than PCyR	No CyR
12	CCyR	Less than PCyR	CCyR	PCyR	Less than PCyR
18	CCyR	Less than CCyR	MMR	Less than MMR	Less than CCyR

Abbreviations: CHR, complete hematologic response (white blood cell count < 10 × 10⁹/L, platelet count < 450 × 10⁹/L, no immature myelocytes, promyelocytes, or blasts in peripheral blood and disappearance of palpable splenomegaly); CCyR, complete cytogenetic response (no Ph+ metaphases); CyR, cytogenetic response; mCyR, minor cytogenetic response (> 35% Ph+ metaphases); MMR, major molecular response (reduction in BCR-ABL/control gene ratio; ≥ 3-log reduction from a standardized based or ≤ 0.1 % on the international scale); PCyR, partial cytogenetic response (1%–35% Ph+ metaphases).