Table 5.
Selected Toxicities of Nilotinib and Imatinib in the ENESTnd Study26
| Toxicity | All Grades (%) |
Grade 3 or 4 (%) |
||||
|---|---|---|---|---|---|---|
| Nilotinib 300 mg twice daily |
Nilotinib 400 mg twice daily |
Imatinib 400 mg daily |
Nilotinib 300 mg twice daily |
Nilotinib 400 mg twice daily |
Imatinib 400 mg daily |
|
| Hematologic Toxicities | ||||||
| Neutropenia | 43 | 38 | 68 | 12 | 10 | 20 |
| Thrombocytopenia | 48 | 49 | 56 | 10 | 12 | 9 |
| Anemia | 38 | 38 | 47 | 3 | 3 | 5 |
| Nonhematologic Toxicities | ||||||
| Peripheral edema | 5 | 5 | 14 | 0 | 0 | 0 |
| Diarrhea | 8 | 6 | 21 | 1 | 0 | 1 |
| Nausea | 11 | 19 | 31 | < 1 | 1 | 0 |
| Vomiting | 5 | 9 | 14 | 0 | 1 | 0 |
| Muscle spasm | 7 | 6 | 24 | 0 | 1 | 1 |
| Rash | 31 | 36 | 11 | < 1 | 3 | 1 |
| Headache | 14 | 21 | 8 | 1 | 1 | 0 |
| Fatigue | 11 | 9 | 8 | 0 | 1 | < 1 |