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. Author manuscript; available in PMC: 2014 Nov 17.
Published in final edited form as: Cell Rep. 2014 Sep 18;8(6):1919–1929. doi: 10.1016/j.celrep.2014.08.025

Figure 3. Brd4 Suppression Promotes Epithelial Hyperplasia and Follicular Defects in the Skin.

Figure 3

(A) Representative hematoxylin and eosin (H&E) and immunofluorescent stains of dorsal skin sections from CAGrtTA3/+; TtG-Ren.713 and CAG rtTA3/+; TtG-Brd4.552 mice on the dox diet for 2 weeks, showing hair shaft defects and epithelial hyperplasia. The bottom panels show dorsal skin sections in CAGrtTA3/+; TtG-Brd4.552 mice following 5 weeks of dox treatment and 2 weeks of subsequent dox withdrawal. Scale bars are indicated.

(B) Image of a CAGrtTA3/+; TtG-Brd4.552 and littermate control CAGrtTA3/+; TtG Ren.713 mouse following 5 weeks of doxycycline treatment and 2 weeks of subsequent dox withdrawal.

(C) Full-thickness scans of H&E-stained dorsal skin sections from CAGrtTA3/+; TtG-Ren713 and CAGrtTA3/+; TtG-Brd4.552 mice after 2 weeks of dox treatment (left and middle) and CAGrtTA3/+; TtG-Brd4.552 skin after 5 weeks of dox treatment and dox withdrawal (right).