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. 2014 Apr 8;11:67. doi: 10.1186/1743-422X-11-67

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Copyright © 2014 Zhang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The pathology detection following inoculated with BVDV JL-1. Histopathology appearances of H&E-stain (A and B), A. spleen, showing the significantly wided periarterial lymphatic sheath and lymphocytes depletion in red pulp (100×); B. intestines: showing hemorrhage and shedding in the small intestine villi (100×). Immunohistochemistry (IHC) detection of BVDV antigen (C and D). C. spleen, virus antigens in mononuclear cells randomly scattered in splenic red pulp (200×); D. virus antigens in epithelium of intestines (200×).