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. 2014 Mar 21;12:20. doi: 10.1186/1741-7007-12-20

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Copyright © 2014 Niepel et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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pAKT response of IGF-1 is negatively correlated with pErbB2 basal level. (A) Correlation of pAKT fold-change response in cells exposed to 100 ng/ml IGF-1 plotted as in 5A. (B) Distribution of relevant RTK expression or phosphorylation levels between lines exhibiting significant (red) or not significant (gray) pAKT response to IGF-1. Black lines represent the median, shaded zones the interquartile range, dashed lines the 5% and 95% quantiles, and dots the outliers. P-values were assessed by a Wilcoxon rank-sum test. (C) Projection of IGF1R and pErbB2 levels in each cell line overlaid with pAKT fold-change response in cells exposed to IGF-1.