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. 2014 Mar 21;12:20. doi: 10.1186/1741-7007-12-20

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Copyright © 2014 Niepel et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Flow chart of dependencies between basal levels and induced levels. This is a heuristic summarizing the primary determinants of cellular response to ligands at the level of pAKT and pERK. See text for details.